This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for PARVB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARVB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARVB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:43,812,012–43,812,763 | 211.9 kb | Distal (>10kb) Multiome | 493 | |
| chr22:43,861,938–43,862,881 | 161.8 kb | Distal (>10kb) Multiome | 263 | |
| chr22:43,891,548–43,892,393 | 132.3 kb | Distal (>10kb) Multiome | 185 | |
| chr22:43,923,130–43,924,772 | 100.5 kb | Distal (>10kb) Multiome | 741 | |
| chr22:43,925,117–43,926,046 | 98.7 kb | Distal (>10kb) Multiome | 441 | |
| chr22:43,955,027–43,955,843 | 68.8 kb | Distal (>10kb) Multiome | 809 | |
| chr22:44,023,900–44,024,505 | 51 bp | At TSS Multiome | 355 | |
| chr22:44,046,421–44,047,108 | 22.6 kb | Distal (>10kb) Multiome | 200 | |
| chr22:44,147,624–44,148,539 | 123.8 kb | Distal (>10kb) Multiome | 144 | |
| chr22:44,661,031–44,661,516 | 636.9 kb | Distal (>10kb) Multiome HiCAR | 28 | |
| chr22:44,668,163–44,669,181 | 644.3 kb | Distal (>10kb) Multiome HiCAR | 265 |
Genomic view of the PARVB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.