Enables polyamine oxidase activity. Involved in polyamine metabolic process and positive regulation of spermidine biosynthetic process. Predicted to be located in cytosol and peroxisomal matrix. Predicted to be active in cytoplasm. Implicated in lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PAOX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAOX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAOX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:133,087,734–133,088,838 | 291.3 kb | Distal (>10kb) Multiome | 273 | |
| chr10:133,143,227–133,144,444 | 235.2 kb | Distal (>10kb) Multiome | 346 | |
| chr10:133,159,602–133,160,521 | 219.1 kb | Distal (>10kb) Multiome | 198 | |
| chr10:133,229,278–133,231,486 | 149.0 kb | Distal (>10kb) Multiome | 253 | |
| chr10:133,231,897–133,232,673 | 146.9 kb | Distal (>10kb) Multiome | 75 | |
| chr10:133,235,225–133,235,826 | 143.6 kb | Distal (>10kb) Multiome | 122 | |
| chr10:133,236,052–133,238,686 | 141.5 kb | Distal (>10kb) Multiome | 361 | |
| chr10:133,245,223–133,246,111 | 133.4 kb | Distal (>10kb) Multiome | 265 | |
| chr10:133,247,041–133,247,539 | 132.0 kb | Distal (>10kb) Multiome | 168 | |
| chr10:133,257,420–133,258,249 | 121.5 kb | Distal (>10kb) Multiome | 384 | |
| chr10:133,261,265–133,262,426 | 117.3 kb | Distal (>10kb) Multiome | 421 | |
| chr10:133,276,420–133,277,460 | 102.3 kb | Distal (>10kb) Multiome | 216 | |
| chr10:133,307,807–133,309,623 | 70.1 kb | Distal (>10kb) Multiome | 785 | |
| chr10:133,318,523–133,319,017 | 60.4 kb | Distal (>10kb) Multiome | 567 | |
| chr10:133,324,203–133,325,065 | 54.8 kb | Distal (>10kb) Multiome | 243 | |
| chr10:133,329,452–133,330,224 | 49.4 kb | Distal (>10kb) Multiome | 471 | |
| chr10:133,357,077–133,358,582 | 21.4 kb | Distal (>10kb) Multiome | 649 | |
| chr10:133,373,095–133,373,842 | 5.8 kb | Proximal (<10kb) Multiome | 589 | |
| chr10:133,377,993–133,380,099 | at TSS | At TSS Multiome | 714 | |
| chr10:133,393,908–133,394,705 | 14.9 kb | Distal (>10kb) Multiome | 959 |
Genomic view of the PAOX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.