Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PAMR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAMR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAMR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:35,525,471–35,526,213 | 200 bp | At TSS Multiome | 283 | |
| chr11:35,526,461–35,526,738 | 845 bp | At TSS | 154 | |
| chr11:35,529,993–35,530,312 | 4.4 kb | Proximal (<10kb) | 102 | |
| chr11:35,617,628–35,620,590 | 92.6 kb | Distal (>10kb) Multiome | 755 | |
| chr11:35,662,341–35,663,428 | 137.2 kb | Distal (>10kb) Multiome | 1145 | |
| chr11:35,821,506–35,822,608 | 296.4 kb | Distal (>10kb) Multiome | 433 |
Genomic view of the PAMR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.