This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for PAK6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAK6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAK6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,038,862–40,039,388 | 213.4 kb | Distal (>10kb) Multiome | 750 | |
| chr15:40,108,639–40,109,491 | 143.5 kb | Distal (>10kb) Multiome | 798 | |
| chr15:40,160,791–40,161,326 | 91.5 kb | Distal (>10kb) Multiome | 762 | |
| chr15:40,323,099–40,324,127 | 70.9 kb | Distal (>10kb) Multiome | 737 | |
| chr15:40,357,707–40,358,772 | 105.7 kb | Distal (>10kb) Multiome | 515 | |
| chr15:40,367,875–40,368,398 | 115.6 kb | Distal (>10kb) Multiome | 846 | |
| chr15:40,405,523–40,406,103 | 153.2 kb | Distal (>10kb) Multiome | 672 | |
| chr15:40,440,664–40,441,222 | 188.4 kb | Distal (>10kb) Multiome | 440 | |
| chr15:40,470,654–40,471,315 | 218.4 kb | Distal (>10kb) Multiome | 463 | |
| chr15:40,511,458–40,512,083 | 259.2 kb | Distal (>10kb) Multiome | 646 |
Genomic view of the PAK6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.