Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PAIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:139,197,672–139,198,627 | 143.5 kb | Distal (>10kb) Multiome | 851 | |
| chr5:139,273,424–139,274,448 | 67.8 kb | Distal (>10kb) Multiome | 843 | |
| chr5:139,283,068–139,284,092 | 58.2 kb | Distal (>10kb) Multiome | 194 | |
| chr5:139,293,312–139,294,807 | 48.1 kb | Distal (>10kb) Multiome | 994 | |
| chr5:139,341,351–139,342,686 | 5 bp | At TSS Multiome | 1002 | |
| chr5:139,378,115–139,378,885 | 36.6 kb | Distal (>10kb) Multiome | 122 | |
| chr5:139,391,978–139,393,556 | 50.9 kb | Distal (>10kb) Multiome | 424 | |
| chr5:139,396,045–139,397,275 | 55.0 kb | Distal (>10kb) Multiome | 134 | |
| chr5:139,403,383–139,404,694 | 62.2 kb | Distal (>10kb) Multiome | 772 | |
| chr5:139,438,861–139,439,913 | 97.5 kb | Distal (>10kb) Multiome | 726 | |
| chr5:139,517,739–139,518,561 | 176.3 kb | Distal (>10kb) Multiome | 1046 | |
| chr5:139,523,548–139,524,678 | 182.3 kb | Distal (>10kb) Multiome | 320 | |
| chr5:139,560,824–139,562,261 | 219.4 kb | Distal (>10kb) Multiome | 970 | |
| chr5:139,637,254–139,638,208 | 295.8 kb | Distal (>10kb) Multiome | 890 |
Genomic view of the PAIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.