The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PAG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:80,872,951–80,874,989 | 237.7 kb | Distal (>10kb) Multiome | 616 | |
| chr8:81,108,224–81,108,458 | 3.6 kb | Proximal (<10kb) | 42 | |
| chr8:81,108,584–81,109,047 | 3.0 kb | Proximal (<10kb) | 51 | |
| chr8:81,111,109–81,112,761 | 100 bp | At TSS Multiome | 605 | |
| chr8:81,115,606–81,116,105 | 3.5 kb | Proximal (<10kb) | 49 | |
| chr8:81,279,926–81,282,008 | 168.4 kb | Distal (>10kb) Multiome | 825 | |
| chr8:81,337,563–81,338,761 | 226.2 kb | Distal (>10kb) Multiome | 183 |
Genomic view of the PAG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.