The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for P4HTM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = P4HTM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of P4HTM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,716,958–48,717,863 | 272.6 kb | Distal (>10kb) Multiome | 634 | |
| chr3:48,847,059–48,848,224 | 142.1 kb | Distal (>10kb) Multiome | 772 | |
| chr3:48,898,423–48,899,110 | 91.0 kb | Distal (>10kb) Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 71.1 kb | Distal (>10kb) Multiome | 877 | |
| chr3:48,987,926–48,988,111 | 1.8 kb | Proximal (<10kb) | 172 | |
| chr3:48,989,537–48,991,069 | 164 bp | At TSS Multiome | 552 | |
| chr3:49,003,975–49,004,995 | 14.6 kb | Distal (>10kb) Multiome | 209 | |
| chr3:49,006,738–49,008,496 | 18.0 kb | Distal (>10kb) Multiome | 955 | |
| chr3:49,017,789–49,018,870 | 28.6 kb | Distal (>10kb) Multiome | 780 | |
| chr3:49,020,066–49,022,597 | 31.9 kb | Distal (>10kb) Multiome | 1064 | |
| chr3:49,028,856–49,029,800 | 39.5 kb | Distal (>10kb) Multiome | 974 | |
| chr3:49,093,005–49,094,956 | 104.4 kb | Distal (>10kb) Multiome | 944 | |
| chr3:49,104,279–49,105,309 | 114.9 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,120,575–49,121,282 | 131.0 kb | Distal (>10kb) Multiome | 765 | |
| chr3:49,132,603–49,133,965 | 143.8 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 176.4 kb | Distal (>10kb) Multiome | 622 | |
| chr3:49,170,896–49,171,950 | 181.5 kb | Distal (>10kb) Multiome | 781 | |
| chr3:49,276,912–49,277,398 | 287.2 kb | Distal (>10kb) Multiome | 291 |
Genomic view of the P4HTM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.