The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for P3H3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = P3H3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of P3H3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:6,533,253–6,535,726 | 294.1 kb | Distal (>10kb) Multiome | 1131 | |
| chr12:6,539,914–6,540,883 | 287.7 kb | Distal (>10kb) Multiome | 427 | |
| chr12:6,554,111–6,554,621 | 274.1 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,555,532–6,556,318 | 272.3 kb | Distal (>10kb) Multiome | 551 | |
| chr12:6,567,822–6,568,719 | 260.0 kb | Distal (>10kb) Multiome | 837 | |
| chr12:6,605,947–6,607,790 | 220.9 kb | Distal (>10kb) Multiome | 774 | |
| chr12:6,613,155–6,614,551 | 214.3 kb | Distal (>10kb) Multiome HiCAR | 810 | |
| chr12:6,620,128–6,620,868 | 207.9 kb | Distal (>10kb) Multiome | 239 | |
| chr12:6,662,802–6,663,663 | 165.2 kb | Distal (>10kb) Multiome | 868 | |
| chr12:6,688,517–6,690,027 | 139.0 kb | Distal (>10kb) Multiome | 943 | |
| chr12:6,699,959–6,700,887 | 127.9 kb | Distal (>10kb) Multiome | 263 | |
| chr12:6,723,658–6,724,773 | 104.3 kb | Distal (>10kb) Multiome | 1065 | |
| chr12:6,752,554–6,754,332 | 74.9 kb | Distal (>10kb) Multiome HiCAR | 975 | |
| chr12:6,763,677–6,764,983 | 64.0 kb | Distal (>10kb) Multiome HiCAR | 570 | |
| chr12:6,765,172–6,767,791 | 62.1 kb | Distal (>10kb) Multiome HiCAR | 824 | |
| chr12:6,768,329–6,769,331 | 59.3 kb | Distal (>10kb) Multiome HiCAR | 249 | |
| chr12:6,778,736–6,779,459 | 49.4 kb | Distal (>10kb) Multiome | 777 | |
| chr12:6,821,268–6,822,155 | 6.7 kb | Proximal (<10kb) Multiome | 299 | |
| chr12:6,825,458–6,825,915 | 2.7 kb | Proximal (<10kb) Multiome | 404 | |
| chr12:6,827,303–6,827,685 | 720 bp | At TSS | 292 | |
| chr12:6,828,101–6,829,966 | 1.2 kb | Proximal (<10kb) Multiome HiCAR | 689 | |
| chr12:6,835,724–6,836,002 | 7.3 kb | Proximal (<10kb) | 272 | |
| chr12:6,851,017–6,853,279 | 23.9 kb | Distal (>10kb) Multiome | 966 | |
| chr12:6,866,801–6,870,175 | 39.1 kb | Distal (>10kb) Multiome | 887 | |
| chr12:6,871,062–6,874,199 | 43.9 kb | Distal (>10kb) Multiome | 947 | |
| chr12:6,890,735–6,891,820 | 62.8 kb | Distal (>10kb) Multiome | 908 | |
| chr12:6,904,217–6,905,282 | 76.4 kb | Distal (>10kb) Multiome | 566 | |
| chr12:6,914,274–6,914,898 | 86.1 kb | Distal (>10kb) Multiome | 536 | |
| chr12:6,924,156–6,924,592 | 96.1 kb | Distal (>10kb) Multiome | 458 | |
| chr12:6,925,828–6,926,431 | 97.6 kb | Distal (>10kb) Multiome | 407 | |
| chr12:6,927,411–6,928,051 | 99.4 kb | Distal (>10kb) Multiome | 493 | |
| chr12:6,936,709–6,938,342 | 109.6 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:6,942,356–6,945,492 | 115.8 kb | Distal (>10kb) Multiome | 1205 | |
| chr12:6,945,587–6,947,099 | 118.0 kb | Distal (>10kb) Multiome | 618 | |
| chr12:6,961,769–6,963,542 | 134.8 kb | Distal (>10kb) Multiome | 682 | |
| chr12:6,964,932–6,965,569 | 136.8 kb | Distal (>10kb) Multiome | 549 | |
| chr12:6,970,111–6,971,189 | 142.4 kb | Distal (>10kb) Multiome | 899 | |
| chr12:7,018,028–7,019,126 | 190.3 kb | Distal (>10kb) Multiome | 824 | |
| chr12:7,108,059–7,109,582 | 280.9 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the P3H3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.