This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for OXSM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OXSM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OXSM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:25,647,592–25,648,802 | 135.0 kb | Distal (>10kb) Multiome | 394 | |
| chr3:25,663,351–25,665,698 | 118.1 kb | Distal (>10kb) Multiome HiCAR | 919 | |
| chr3:25,772,918–25,773,143 | 9.9 kb | Proximal (<10kb) | 4 | |
| chr3:25,782,726–25,784,290 | 477 bp | At TSS Multiome | 858 | |
| chr3:25,789,801–25,790,575 | 7.1 kb | Proximal (<10kb) Multiome | 893 |
Genomic view of the OXSM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.