Predicted to enable oxidoreductase activity. Predicted to be involved in response to oxidative stress. Predicted to act upstream of or within several processes, including adult walking behavior; negative regulation of cellular response to oxidative stress; and negative regulation of peptidyl-cysteine S-nitrosylation. Located in mitochondrion. Implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for OXR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OXR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OXR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:106,261,147–106,261,549 | 8.6 kb | Proximal (<10kb) | 18 | |
| chr8:106,269,029–106,272,090 | 73 bp | At TSS Multiome | 840 | |
| chr8:106,657,071–106,658,784 | 387.6 kb | Distal (>10kb) Multiome | 859 | |
| chr8:106,660,408–106,660,682 | 2.5 kb | Proximal (<10kb) | 15 | |
| chr8:106,663,559–106,664,206 | 5.7 kb | Proximal (<10kb) | 23 | |
| chr8:106,794,641–106,795,620 | 525.1 kb | Distal (>10kb) Multiome | 176 |
Genomic view of the OXR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.