Located in cytoplasmic side of endoplasmic reticulum membrane and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OTULINL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OTULINL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OTULINL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:14,560,146–14,560,831 | 21.3 kb | Distal (>10kb) Multiome | 163 | |
| chr5:14,577,247–14,577,740 | 4.0 kb | Proximal (<10kb) | 65 | |
| chr5:14,581,121–14,582,834 | 35 bp | At TSS Multiome | 552 | |
| chr5:14,588,924–14,589,595 | 7.1 kb | Proximal (<10kb) | 90 | |
| chr5:14,663,826–14,665,619 | 82.8 kb | Distal (>10kb) Multiome | 997 | |
| chr5:14,727,409–14,729,005 | 146.8 kb | Distal (>10kb) Multiome | 628 | |
| chr5:14,871,212–14,873,334 | 290.1 kb | Distal (>10kb) Multiome | 600 |
Genomic view of the OTULINL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.