This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for OTUB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OTUB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OTUB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:93,787,427–93,789,655 | 237.7 kb | Distal (>10kb) Multiome | 458 | |
| chr14:93,938,972–93,940,225 | 86.7 kb | Distal (>10kb) Multiome | 431 | |
| chr14:94,026,129–94,026,981 | 21 bp | At TSS Multiome | 519 | |
| chr14:94,034,339–94,034,733 | 8.0 kb | Proximal (<10kb) | 14 | |
| chr14:94,036,395–94,037,000 | 10.3 kb | Distal (>10kb) Multiome | 225 | |
| chr14:94,080,803–94,081,695 | 54.9 kb | Distal (>10kb) Multiome | 679 | |
| chr14:94,129,110–94,129,887 | 103.2 kb | Distal (>10kb) Multiome | 322 | |
| chr14:94,173,317–94,175,546 | 147.8 kb | Distal (>10kb) Multiome HiCAR | 517 |
Genomic view of the OTUB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.