This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for OSBPL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBPL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBPL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:2,883,795–2,886,948 | 279.4 kb | Distal (>10kb) Multiome | 639 | |
| chr11:2,891,828–2,893,111 | 272.8 kb | Distal (>10kb) Multiome | 572 | |
| chr11:2,901,621–2,903,073 | 263.1 kb | Distal (>10kb) Multiome | 610 | |
| chr11:2,928,807–2,931,249 | 234.5 kb | Distal (>10kb) Multiome | 770 | |
| chr11:2,991,519–2,993,201 | 173.0 kb | Distal (>10kb) Multiome | 759 | |
| chr11:3,056,953–3,057,972 | 107.8 kb | Distal (>10kb) Multiome | 798 | |
| chr11:3,091,645–3,092,317 | 73.4 kb | Distal (>10kb) Multiome | 449 | |
| chr11:3,148,512–3,149,454 | 16.4 kb | Distal (>10kb) Multiome | 152 | |
| chr11:3,160,043–3,161,026 | 4.8 kb | Proximal (<10kb) Multiome | 283 | |
| chr11:3,164,925–3,165,485 | 92 bp | At TSS Multiome | 326 | |
| chr11:3,378,728–3,379,430 | 213.8 kb | Distal (>10kb) Multiome | 821 | |
| chr11:3,380,404–3,381,449 | 215.5 kb | Distal (>10kb) Multiome | 195 | |
| chr11:3,421,770–3,423,686 | 257.6 kb | Distal (>10kb) Multiome | 328 |
Genomic view of the OSBPL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.