Involved in ceramide metabolic process. Acts upstream of or within several processes, including negative regulation of B cell apoptotic process; negative regulation of ceramide biosynthetic process; and positive regulation of protein localization to nucleus. Located in endoplasmic reticulum. Part of serine palmitoyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ORMDL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ORMDL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ORMDL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:39,636,769–39,637,600 | 290.4 kb | Distal (>10kb) Multiome | 853 | |
| chr17:39,652,588–39,653,348 | 274.6 kb | Distal (>10kb) Multiome | 263 | |
| chr17:39,668,234–39,668,690 | 259.1 kb | Distal (>10kb) Multiome | 706 | |
| chr17:39,687,710–39,688,437 | 239.6 kb | Distal (>10kb) Multiome | 800 | |
| chr17:39,695,905–39,696,636 | 231.3 kb | Distal (>10kb) Multiome | 499 | |
| chr17:39,699,516–39,700,527 | 227.7 kb | Distal (>10kb) Multiome | 528 | |
| chr17:39,730,039–39,730,906 | 197.1 kb | Distal (>10kb) Multiome | 886 | |
| chr17:39,739,067–39,739,915 | 188.1 kb | Distal (>10kb) Multiome | 648 | |
| chr17:39,740,384–39,740,910 | 186.9 kb | Distal (>10kb) Multiome | 513 | |
| chr17:39,753,811–39,754,996 | 173.2 kb | Distal (>10kb) Multiome | 1000 | |
| chr17:39,926,716–39,928,343 | 96 bp | At TSS Multiome | 942 | |
| chr17:39,952,356–39,953,923 | 25.5 kb | Distal (>10kb) Multiome | 598 | |
| chr17:39,979,964–39,981,234 | 53.0 kb | Distal (>10kb) Multiome | 1148 | |
| chr17:40,054,311–40,054,810 | 126.9 kb | Distal (>10kb) Multiome | 694 | |
| chr17:40,062,700–40,063,624 | 135.4 kb | Distal (>10kb) Multiome | 609 | |
| chr17:40,075,390–40,075,997 | 148.1 kb | Distal (>10kb) Multiome | 556 | |
| chr17:40,098,950–40,099,858 | 171.6 kb | Distal (>10kb) Multiome | 997 | |
| chr17:40,100,155–40,101,301 | 173.2 kb | Distal (>10kb) Multiome | 954 | |
| chr17:40,111,702–40,112,164 | 184.2 kb | Distal (>10kb) Multiome | 678 | |
| chr17:40,113,185–40,113,691 | 185.8 kb | Distal (>10kb) Multiome | 864 | |
| chr17:40,121,452–40,123,602 | 194.3 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,139,909–40,141,108 | 212.8 kb | Distal (>10kb) Multiome | 1121 | |
| chr17:40,177,152–40,178,398 | 249.9 kb | Distal (>10kb) Multiome | 329 | |
| chr17:40,191,326–40,192,022 | 264.2 kb | Distal (>10kb) Multiome | 588 | |
| chr17:40,218,712–40,219,963 | 291.8 kb | Distal (>10kb) Multiome | 901 |
Genomic view of the ORMDL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.