Enables G protein-coupled enkephalin receptor activity. Involved in several processes, including G protein-coupled opioid receptor signaling pathway; cellular response to hypoxia; and positive regulation of peptidyl-serine phosphorylation. Located in plasma membrane. Implicated in alcohol dependence; alcohol use disorder; drug dependence (multiple); opioid abuse; and withdrawal disorder. Biomarker of opioid abuse. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for OPRD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OPRD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OPRD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:28,513,136–28,516,505 | 296.7 kb | Distal (>10kb) Multiome | 461 | |
| chr1:28,517,302–28,519,364 | 293.8 kb | Distal (>10kb) Multiome | 927 | |
| chr1:28,552,370–28,553,806 | 259.2 kb | Distal (>10kb) Multiome | 955 | |
| chr1:28,580,985–28,582,501 | 230.3 kb | Distal (>10kb) Multiome | 1080 | |
| chr1:28,592,018–28,592,768 | 219.9 kb | Distal (>10kb) Multiome | 394 | |
| chr1:28,642,403–28,643,726 | 169.0 kb | Distal (>10kb) Multiome | 980 | |
| chr1:28,648,003–28,650,002 | 163.4 kb | Distal (>10kb) Multiome | 1377 | |
| chr1:28,667,742–28,669,783 | 143.3 kb | Distal (>10kb) Multiome | 804 | |
| chr1:28,736,098–28,738,080 | 75.5 kb | Distal (>10kb) Multiome | 1106 | |
| chr1:28,811,880–28,812,661 | 151 bp | At TSS Multiome | 219 | |
| chr1:28,881,894–28,882,433 | 70.1 kb | Distal (>10kb) Multiome | 615 | |
| chr1:28,886,723–28,888,425 | 74.9 kb | Distal (>10kb) Multiome | 709 | |
| chr1:28,913,920–28,915,470 | 102.3 kb | Distal (>10kb) Multiome | 738 |
Genomic view of the OPRD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.