This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for OPCML. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OPCML upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OPCML, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:132,792,438–132,793,956 | 150.1 kb | Distal (>10kb) Multiome | 153 | |
| chr11:132,886,272–132,886,758 | 56.5 kb | Distal (>10kb) Multiome | 165 | |
| chr11:132,942,643–132,944,527 | 1.1 kb | Proximal (<10kb) Multiome | 203 | |
| chr11:133,021,503–133,022,080 | 78.8 kb | Distal (>10kb) Multiome | 24 | |
| chr11:133,038,814–133,039,371 | 96.0 kb | Distal (>10kb) Multiome | 74 | |
| chr11:133,063,951–133,064,907 | 121.4 kb | Distal (>10kb) Multiome HiCAR | 343 | |
| chr11:133,082,587–133,083,765 | 140.0 kb | Distal (>10kb) Multiome | 389 | |
| chr11:133,228,479–133,229,257 | 286.0 kb | Distal (>10kb) Multiome | 198 | |
| chr11:133,530,226–133,530,792 | 1.6 kb | Proximal (<10kb) | 75 | |
| chr11:133,531,589–133,532,809 | at TSS | At TSS | 66 | |
| chr11:133,541,123–133,542,089 | 8.7 kb | Proximal (<10kb) | 180 |
Genomic view of the OPCML locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.