This is a conserved gene that produces a long non-coding RNA that maintains cell proliferation in embryonic stem cells. This RNA can bind to and negatively regulate the activity of multiple cellular RNAs and microRNAs, including cyclin G associated kinase and ELAV like RNA binding protein 1. [provided by RefSeq, Dec 2017]
Transcription factors with Perturb-seq knockdown data for OIP5-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OIP5-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OIP5-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:41,115,645–41,116,753 | 167.6 kb | Distal (>10kb) Multiome | 909 | |
| chr15:41,230,581–41,231,535 | 52.9 kb | Distal (>10kb) Multiome | 1063 | |
| chr15:41,283,739–41,284,308 | 42 bp | At TSS Multiome | 798 | |
| chr15:41,332,102–41,333,206 | 48.7 kb | Distal (>10kb) Multiome | 883 | |
| chr15:41,416,690–41,417,765 | 133.1 kb | Distal (>10kb) Multiome | 734 | |
| chr15:41,493,120–41,493,918 | 209.7 kb | Distal (>10kb) Multiome | 692 | |
| chr15:41,543,905–41,544,403 | 260.2 kb | Distal (>10kb) Multiome | 687 | |
| chr15:41,558,746–41,559,337 | 275.2 kb | Distal (>10kb) Multiome | 358 |
Genomic view of the OIP5-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.