This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for ODAD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ODAD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ODAD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:41,647,765–41,648,495 | 282.6 kb | Distal (>10kb) Multiome | 519 | |
| chr17:41,662,549–41,663,015 | 267.8 kb | Distal (>10kb) Multiome | 643 | |
| chr17:41,665,564–41,667,291 | 263.4 kb | Distal (>10kb) Multiome | 883 | |
| chr17:41,688,103–41,690,064 | 241.8 kb | Distal (>10kb) Multiome | 1236 | |
| chr17:41,733,761–41,735,187 | 195.9 kb | Distal (>10kb) Multiome | 577 | |
| chr17:41,738,054–41,738,690 | 192.4 kb | Distal (>10kb) Multiome | 596 | |
| chr17:41,784,980–41,787,229 | 143.8 kb | Distal (>10kb) Multiome | 958 | |
| chr17:41,793,527–41,794,326 | 136.8 kb | Distal (>10kb) Multiome | 597 | |
| chr17:41,800,647–41,802,040 | 128.7 kb | Distal (>10kb) Multiome | 766 | |
| chr17:41,811,252–41,813,275 | 117.7 kb | Distal (>10kb) Multiome | 997 | |
| chr17:41,835,756–41,836,400 | 94.4 kb | Distal (>10kb) Multiome | 568 | |
| chr17:41,864,608–41,865,695 | 65.2 kb | Distal (>10kb) Multiome | 913 | |
| chr17:41,913,670–41,914,569 | 16.6 kb | Distal (>10kb) Multiome | 190 | |
| chr17:41,918,026–41,919,794 | 11.4 kb | Distal (>10kb) Multiome | 956 | |
| chr17:41,930,220–41,930,908 | 118 bp | At TSS Multiome | 915 | |
| chr17:41,965,771–41,967,327 | 36.1 kb | Distal (>10kb) Multiome | 920 | |
| chr17:42,016,953–42,018,102 | 86.8 kb | Distal (>10kb) Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 89.4 kb | Distal (>10kb) Multiome | 791 | |
| chr17:42,050,326–42,051,046 | 120.0 kb | Distal (>10kb) Multiome | 514 | |
| chr17:42,107,497–42,108,335 | 177.2 kb | Distal (>10kb) Multiome | 357 | |
| chr17:42,120,858–42,121,715 | 190.6 kb | Distal (>10kb) Multiome | 559 | |
| chr17:42,122,176–42,123,003 | 192.1 kb | Distal (>10kb) Multiome | 169 | |
| chr17:42,154,717–42,156,309 | 224.5 kb | Distal (>10kb) Multiome | 770 | |
| chr17:42,183,755–42,184,761 | 253.6 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the ODAD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.