This gene encodes a protein containing coiled-coil domains. The encoded protein functions in outer dynein arm assembly and is required for motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Transcription factors with Perturb-seq knockdown data for ODAD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ODAD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ODAD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,137,551–11,138,233 | 297.3 kb | Distal (>10kb) Multiome | 584 | |
| chr19:11,155,520–11,156,298 | 279.3 kb | Distal (>10kb) Multiome | 754 | |
| chr19:11,196,759–11,198,184 | 237.5 kb | Distal (>10kb) Multiome | 728 | |
| chr19:11,243,345–11,243,968 | 191.7 kb | Distal (>10kb) Multiome | 448 | |
| chr19:11,262,060–11,262,653 | 172.7 kb | Distal (>10kb) Multiome | 406 | |
| chr19:11,339,100–11,339,837 | 95.5 kb | Distal (>10kb) Multiome | 506 | |
| chr19:11,346,053–11,346,958 | 88.7 kb | Distal (>10kb) Multiome | 676 | |
| chr19:11,355,078–11,355,735 | 79.8 kb | Distal (>10kb) Multiome | 382 | |
| chr19:11,361,368–11,362,625 | 73.5 kb | Distal (>10kb) Multiome | 256 | |
| chr19:11,374,474–11,375,717 | 60.2 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,380,761–11,382,262 | 53.8 kb | Distal (>10kb) Multiome | 798 | |
| chr19:11,382,830–11,384,509 | 50.8 kb | Distal (>10kb) Multiome | 761 | |
| chr19:11,418,061–11,419,498 | 16.6 kb | Distal (>10kb) Multiome | 421 | |
| chr19:11,420,614–11,422,979 | 13.0 kb | Distal (>10kb) Multiome | 507 | |
| chr19:11,434,817–11,436,365 | 167 bp | At TSS Multiome | 927 | |
| chr19:11,479,217–11,480,146 | 44.5 kb | Distal (>10kb) Multiome | 394 | |
| chr19:11,481,847–11,483,040 | 47.5 kb | Distal (>10kb) Multiome | 938 | |
| chr19:11,504,741–11,506,612 | 70.2 kb | Distal (>10kb) Multiome | 854 | |
| chr19:11,528,581–11,529,391 | 93.9 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,535,847–11,536,353 | 101.0 kb | Distal (>10kb) Multiome | 694 | |
| chr19:11,538,464–11,539,111 | 103.6 kb | Distal (>10kb) Multiome | 235 | |
| chr19:11,539,738–11,540,434 | 104.9 kb | Distal (>10kb) Multiome | 176 | |
| chr19:11,558,908–11,559,777 | 124.1 kb | Distal (>10kb) Multiome | 686 | |
| chr19:11,597,206–11,598,107 | 162.3 kb | Distal (>10kb) Multiome | 914 | |
| chr19:11,639,337–11,640,481 | 204.6 kb | Distal (>10kb) Multiome | 660 | |
| chr19:11,694,497–11,695,341 | 259.8 kb | Distal (>10kb) Multiome | 608 |
Genomic view of the ODAD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.