OAS3

2'-5'-oligoadenylate synthetase 3

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

Biological processes 43 terms

2'-5'-oligoadenylate synthetase activity (GO:0001730)2'-5'-oligoadenylate synthetase activity (GO:0001730)2'-5'-oligoadenylate synthetase activity (GO:0001730)ATP binding (GO:0005524)MDA-5 signaling pathway (GO:0039530)RIG-I signaling pathway (GO:0039529)antiviral innate immune response (GO:0140374)cellular response to exogenous dsRNA (GO:0071360)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)defense response (GO:0006952)defense response to bacterium (GO:0042742)defense response to virus (GO:0051607)double-stranded RNA binding (GO:0003725)double-stranded RNA binding (GO:0003725)double-stranded RNA binding (GO:0003725)extracellular region (GO:0005576)interleukin-27-mediated signaling pathway (GO:0070106)intracellular membrane-bounded organelle (GO:0043231)membrane (GO:0016020)negative regulation of IP-10 production (GO:0071659)negative regulation of chemokine (C-C motif) ligand 5 production (GO:0071650)negative regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000342)negative regulation of chemokine (C-X-C motif) ligand 9 production (GO:0035395)negative regulation of type I interferon-mediated signaling pathway (GO:0060339)negative regulation of viral genome replication (GO:0045071)negative regulation of viral genome replication (GO:0045071)nucleobase-containing compound metabolic process (GO:0006139)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleotidyltransferase activity (GO:0016779)nucleus (GO:0005634)positive regulation of interferon-beta production (GO:0032728)positive regulation of monocyte chemotactic protein-1 production (GO:0071639)positive regulation of tumor necrosis factor production (GO:0032760)protein binding (GO:0005515)regulation of ribonuclease activity (GO:0060700)response to virus (GO:0009615)response to virus (GO:0009615)type I interferon-mediated signaling pathway (GO:0060337)

Expression (TPM)