NUPR1
nuclear protein 1, transcriptional regulator | COM1, p8

Enables DNA binding activity and transcription coactivator activity. Involved in several processes, including negative regulation of programmed cell death; positive regulation of oxidative phosphorylation; and regulation of catabolic process. Acts upstream of or within negative regulation of cell cycle. Located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2025]

Biological processes 51 terms
DNA binding (GO:0003677)DNA binding (GO:0003677)acetyltransferase activator activity (GO:0010698)acetyltransferase activator activity (GO:0010698)chromatin binding (GO:0003682)cytoplasm (GO:0005737)cytoplasm (GO:0005737)negative regulation of apoptotic process (GO:0043066)negative regulation of autophagosome assembly (GO:1902902)negative regulation of autophagy (GO:0010507)negative regulation of autophagy (GO:0010507)negative regulation of autophagy (GO:0010507)negative regulation of cardiac muscle cell apoptotic process (GO:0010667)negative regulation of cardiac muscle cell apoptotic process (GO:0010667)negative regulation of cardiac muscle cell apoptotic process (GO:0010667)negative regulation of cell cycle (GO:0045786)negative regulation of cell cycle (GO:0045786)negative regulation of cell population proliferation (GO:0008285)negative regulation of epithelial cell apoptotic process (GO:1904036)negative regulation of epithelial cell apoptotic process (GO:1904036)negative regulation of epithelial cell proliferation (GO:0050680)negative regulation of epithelial cell proliferation (GO:0050680)negative regulation of glycolytic process (GO:0045820)negative regulation of programmed necrotic cell death (GO:0062099)negative regulation of type B pancreatic cell proliferation (GO:1904691)negative regulation of type B pancreatic cell proliferation (GO:1904691)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of cell cycle (GO:0045787)positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)positive regulation of neuroinflammatory response (GO:0150078)positive regulation of neuroinflammatory response (GO:0150078)positive regulation of neuron apoptotic process (GO:0043525)positive regulation of neuron apoptotic process (GO:0043525)positive regulation of oxidative phosphorylation (GO:1903862)positive regulation of proteasomal protein catabolic process (GO:1901800)protein binding (GO:0005515)protein-DNA complex (GO:0032993)regulation of autophagy (GO:0010506)regulation of autophagy (GO:0010506)regulation of response to endoplasmic reticulum stress (GO:1905897)regulation of response to endoplasmic reticulum stress (GO:1905897)regulation of response to endoplasmic reticulum stress (GO:1905897)transcription coactivator activity (GO:0003713)
Expression (TPM)
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