NUP62

nucleoporin 62 | DKFZp547L134, FLJ20822, FLJ43869, IBSN, MGC841, SNDI, p62

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

Member of: DE-6

Biological processes 55 terms

Flemming body (GO:0090543)Hsp70 protein binding (GO:0030544)Hsp90 protein binding (GO:0051879)PTB domain binding (GO:0051425)RNA export from nucleus (GO:0006405)SH2 domain binding (GO:0042169)cell surface receptor signaling pathway (GO:0007166)cell surface receptor signaling pathway (GO:0007166)centriole assembly (GO:0098534)centrosome (GO:0005813)centrosome (GO:0005813)centrosome cycle (GO:0007098)chromatin binding (GO:0003682)cytoplasm (GO:0005737)cytoplasm (GO:0005737)mitotic centrosome separation (GO:0007100)mitotic metaphase chromosome alignment (GO:0007080)mitotic spindle (GO:0072686)negative regulation of Ras protein signal transduction (GO:0046580)negative regulation of apoptotic process (GO:0043066)negative regulation of cell population proliferation (GO:0008285)negative regulation of cell population proliferation (GO:0008285)negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)negative regulation of programmed cell death (GO:0043069)nuclear envelope (GO:0005635)nuclear envelope (GO:0005635)nuclear envelope (GO:0005635)nuclear membrane (GO:0031965)nuclear membrane (GO:0031965)nuclear pore (GO:0005643)nuclear pore (GO:0005643)nuclear pore (GO:0005643)nuclear pore central transport channel (GO:0044613)nucleocytoplasmic transport (GO:0006913)nucleoplasm (GO:0005654)phospholipid binding (GO:0005543)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of centriole replication (GO:0046601)positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)positive regulation of mitotic cytokinetic process (GO:1903438)positive regulation of mitotic nuclear division (GO:0045840)positive regulation of protein localization to centrosome (GO:1904781)protein binding (GO:0005515)protein import into nucleus (GO:0006606)regulation of Ras protein signal transduction (GO:0046578)regulation of mitotic spindle organization (GO:0060236)regulation of signal transduction (GO:0009966)ribonucleoprotein complex (GO:1990904)signaling receptor complex adaptor activity (GO:0030159)spindle pole (GO:0000922)spindle pole (GO:0000922)structural constituent of nuclear pore (GO:0017056)structural constituent of nuclear pore (GO:0017056)ubiquitin binding (GO:0043130)

Expression (TPM)

TFs regulating NUP62 0 TFs

Transcription factors with Perturb-seq knockdown data for NUP62. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP62 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NUP62

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP62, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:49,638,063–49,638,728	291.2 kb	Distal (>10kb) Multiome	237
chr19:49,639,671–49,642,787	289.1 kb	Distal (>10kb) Multiome	1067
chr19:49,664,165–49,665,096	264.9 kb	Distal (>10kb) Multiome	679
chr19:49,665,345–49,666,430	263.6 kb	Distal (>10kb) Multiome	721
chr19:49,672,105–49,672,787	257.1 kb	Distal (>10kb) Multiome	625
chr19:49,676,058–49,678,754	252.5 kb	Distal (>10kb) Multiome	1033
chr19:49,680,433–49,681,147	248.7 kb	Distal (>10kb) Multiome	435
chr19:49,690,485–49,691,761	238.4 kb	Distal (>10kb) Multiome	327
chr19:49,746,188–49,746,748	183.0 kb	Distal (>10kb) Multiome	283
chr19:49,766,231–49,767,440	162.8 kb	Distal (>10kb) Multiome	718
chr19:49,802,146–49,802,787	127.0 kb	Distal (>10kb) Multiome	200
chr19:49,805,226–49,805,871	123.9 kb	Distal (>10kb) Multiome	245
chr19:49,808,201–49,809,746	120.5 kb	Distal (>10kb) Multiome	509
chr19:49,812,926–49,813,834	116.0 kb	Distal (>10kb) Multiome	650
chr19:49,817,356–49,818,721	111.2 kb	Distal (>10kb) Multiome	784
chr19:49,850,394–49,852,067	78.6 kb	Distal (>10kb) Multiome	862
chr19:49,866,817–49,868,124	62.1 kb	Distal (>10kb) Multiome	874
chr19:49,869,068–49,870,398	59.8 kb	Distal (>10kb) Multiome	832
chr19:49,875,842–49,878,576	51.7 kb	Distal (>10kb) Multiome	1153
chr19:49,889,853–49,891,381	39.0 kb	Distal (>10kb) Multiome	640
chr19:49,928,884–49,930,473	445 bp	At TSS Multiome	1141
chr19:49,937,724–49,938,146	8.2 kb	Proximal (<10kb)	444
chr19:49,987,157–49,987,669	57.9 kb	Distal (>10kb) Multiome	1095
chr19:50,024,875–50,026,285	96.2 kb	Distal (>10kb) Multiome	1137
chr19:50,147,523–50,148,432	218.7 kb	Distal (>10kb) Multiome	615
chr19:50,203,034–50,204,072	274.1 kb	Distal (>10kb) Multiome	363
chr19:50,205,195–50,205,903	275.9 kb	Distal (>10kb) Multiome	364

Genome Browser

Genomic view of the NUP62 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.