The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for NUDT14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDT14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDT14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:104,932,604–104,933,678 | 247.9 kb | Distal (>10kb) Multiome | 498 | |
| chr14:104,967,607–104,968,024 | 213.4 kb | Distal (>10kb) Multiome | 196 | |
| chr14:104,975,803–104,976,561 | 205.1 kb | Distal (>10kb) Multiome | 394 | |
| chr14:104,977,531–104,979,147 | 202.9 kb | Distal (>10kb) Multiome | 387 | |
| chr14:104,985,398–104,986,377 | 195.6 kb | Distal (>10kb) Multiome | 518 | |
| chr14:105,020,271–105,022,072 | 160.1 kb | Distal (>10kb) Multiome | 813 | |
| chr14:105,045,704–105,046,235 | 135.4 kb | Distal (>10kb) Multiome | 635 | |
| chr14:105,086,627–105,087,884 | 94.3 kb | Distal (>10kb) Multiome | 590 | |
| chr14:105,090,382–105,091,009 | 90.6 kb | Distal (>10kb) Multiome | 375 | |
| chr14:105,092,908–105,094,307 | 87.4 kb | Distal (>10kb) Multiome | 495 | |
| chr14:105,167,331–105,169,463 | 12.3 kb | Distal (>10kb) Multiome | 496 | |
| chr14:105,180,714–105,181,828 | 64 bp | At TSS Multiome | 392 | |
| chr14:105,248,175–105,249,386 | 67.2 kb | Distal (>10kb) Multiome | 403 | |
| chr14:105,299,994–105,301,984 | 120.0 kb | Distal (>10kb) Multiome | 829 | |
| chr14:105,313,768–105,315,755 | 133.3 kb | Distal (>10kb) Multiome | 584 | |
| chr14:105,352,048–105,352,515 | 171.0 kb | Distal (>10kb) Multiome | 344 | |
| chr14:105,398,137–105,398,986 | 217.2 kb | Distal (>10kb) Multiome | 870 | |
| chr14:105,411,005–105,411,818 | 230.1 kb | Distal (>10kb) Multiome | 384 | |
| chr14:105,414,940–105,415,397 | 233.8 kb | Distal (>10kb) Multiome | 447 | |
| chr14:105,419,281–105,420,109 | 238.5 kb | Distal (>10kb) Multiome | 570 | |
| chr14:105,448,471–105,448,924 | 267.5 kb | Distal (>10kb) Multiome | 304 | |
| chr14:105,473,498–105,475,498 | 293.0 kb | Distal (>10kb) Multiome | 581 | |
| chr14:105,480,543–105,482,375 | 299.7 kb | Distal (>10kb) Multiome | 784 |
Genomic view of the NUDT14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.