This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for NUDC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:26,692,203–26,693,499 | 229.3 kb | Distal (>10kb) Multiome | 974 | |
| chr1:26,695,271–26,696,473 | 226.0 kb | Distal (>10kb) Multiome | 1053 | |
| chr1:26,723,135–26,723,892 | 198.2 kb | Distal (>10kb) Multiome | 671 | |
| chr1:26,786,686–26,788,664 | 133.7 kb | Distal (>10kb) Multiome | 918 | |
| chr1:26,826,166–26,827,148 | 95.1 kb | Distal (>10kb) Multiome | 510 | |
| chr1:26,862,775–26,863,565 | 58.7 kb | Distal (>10kb) Multiome | 486 | |
| chr1:26,864,355–26,865,945 | 56.5 kb | Distal (>10kb) Multiome | 892 | |
| chr1:26,889,797–26,890,628 | 31.5 kb | Distal (>10kb) Multiome | 906 | |
| chr1:26,899,986–26,900,610 | 21.4 kb | Distal (>10kb) Multiome | 792 | |
| chr1:26,913,478–26,914,582 | 7.4 kb | Proximal (<10kb) Multiome | 877 | |
| chr1:26,921,268–26,922,160 | 45 bp | At TSS Multiome | 838 | |
| chr1:26,959,908–26,960,855 | 38.7 kb | Distal (>10kb) Multiome | 607 | |
| chr1:26,992,986–26,995,593 | 71.9 kb | Distal (>10kb) Multiome | 854 | |
| chr1:26,997,489–26,998,161 | 76.1 kb | Distal (>10kb) Multiome | 550 | |
| chr1:27,010,686–27,011,820 | 89.4 kb | Distal (>10kb) Multiome | 379 | |
| chr1:27,012,151–27,013,639 | 91.3 kb | Distal (>10kb) Multiome | 712 | |
| chr1:27,031,351–27,031,956 | 110.0 kb | Distal (>10kb) Multiome | 260 | |
| chr1:27,102,589–27,103,140 | 181.1 kb | Distal (>10kb) Multiome | 263 | |
| chr1:27,154,381–27,155,711 | 233.4 kb | Distal (>10kb) Multiome | 1038 |
Genomic view of the NUDC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.