NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for NUBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:10,579,792–10,580,982 | 163.2 kb | Distal (>10kb) Multiome | 830 | |
| chr16:10,621,860–10,622,627 | 121.6 kb | Distal (>10kb) Multiome | 241 | |
| chr16:10,737,167–10,737,342 | 6.5 kb | Proximal (<10kb) | 303 | |
| chr16:10,743,473–10,744,692 | 293 bp | At TSS Multiome | 1045 | |
| chr16:10,818,333–10,818,889 | 74.7 kb | Distal (>10kb) Multiome | 127 | |
| chr16:10,942,009–10,942,939 | 198.7 kb | Distal (>10kb) Multiome | 627 | |
| chr16:10,944,257–10,944,954 | 200.6 kb | Distal (>10kb) Multiome | 887 | |
| chr16:11,032,660–11,033,355 | 289.2 kb | Distal (>10kb) Multiome | 81 |
Genomic view of the NUBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.