Predicted to be involved in axonogenesis; regulation of cell projection organization; and regulation of neuron migration. Predicted to be located in plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NTNG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NTNG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NTNG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:131,739,378–131,740,405 | 422.0 kb | Distal (>10kb) Multiome HiCAR | 513 | |
| chr9:131,807,487–131,807,943 | 354.3 kb | Distal (>10kb) Multiome HiCAR | 104 | |
| chr9:132,006,745–132,007,281 | 155.0 kb | Distal (>10kb) Multiome | 166 | |
| chr9:132,079,578–132,080,009 | 82.2 kb | Distal (>10kb) Multiome | 537 | |
| chr9:132,154,920–132,155,176 | 6.9 kb | Proximal (<10kb) | 30 | |
| chr9:132,161,591–132,161,821 | 235 bp | At TSS | 205 | |
| chr9:132,161,941–132,162,260 | at TSS | At TSS | 157 | |
| chr9:132,169,879–132,170,069 | 7.8 kb | Proximal (<10kb) | 254 | |
| chr9:132,236,267–132,236,692 | 4.7 kb | Proximal (<10kb) | 244 | |
| chr9:132,239,978–132,242,316 | 79.2 kb | Distal (>10kb) Multiome | 555 | |
| chr9:132,259,091–132,259,539 | 97.3 kb | Distal (>10kb) Multiome | 443 | |
| chr9:132,354,395–132,355,656 | 193.1 kb | Distal (>10kb) Multiome | 895 | |
| chr9:132,409,879–132,410,471 | 248.0 kb | Distal (>10kb) Multiome | 293 | |
| chr9:132,411,065–132,411,553 | 249.2 kb | Distal (>10kb) Multiome | 342 |
Genomic view of the NTNG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.