NTMT1

N-terminal Xaa-Pro-Lys N-methyltransferase 1 | AD-003, HOMT1A, NRMT, NRMT1, C9orf32, METTL11A

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

Member of: DE-1

Biological processes 21 terms

N-terminal peptidyl-glycine methylation (GO:0018013)N-terminal peptidyl-proline dimethylation (GO:0018016)N-terminal peptidyl-serine dimethylation (GO:0035572)N-terminal peptidyl-serine trimethylation (GO:0035573)N-terminal protein N-methyltransferase activity (GO:0071885)N-terminal protein N-methyltransferase activity (GO:0071885)N-terminal protein N-methyltransferase activity (GO:0071885)chromatin remodeling (GO:0006338)chromosome segregation (GO:0007059)cytoplasm (GO:0005737)cytosol (GO:0005829)histone methyltransferase activity (GO:0042054)methyltransferase activity (GO:0008168)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein methyltransferase activity (GO:0008276)protein methyltransferase activity (GO:0008276)spindle organization (GO:0007051)spindle organization (GO:0007051)

Expression (TPM)

TFs regulating NTMT1 0 TFs

Transcription factors with Perturb-seq knockdown data for NTMT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NTMT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NTMT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NTMT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr9:129,177,207–129,178,809	447.9 kb	Distal (>10kb) Multiome HiCAR	824
chr9:129,334,082–129,334,794	291.8 kb	Distal (>10kb) Multiome	928
chr9:129,413,561–129,414,426	212.3 kb	Distal (>10kb) Multiome	753
chr9:129,460,241–129,460,831	165.7 kb	Distal (>10kb) Multiome	701
chr9:129,495,758–129,497,403	129.2 kb	Distal (>10kb) Multiome	973
chr9:129,557,196–129,557,935	68.6 kb	Distal (>10kb) Multiome	718
chr9:129,596,686–129,597,656	29.1 kb	Distal (>10kb) Multiome	700
chr9:129,610,548–129,611,334	15.3 kb	Distal (>10kb) Multiome	630
chr9:129,626,055–129,626,580	56 bp	At TSS Multiome	825
chr9:129,641,895–129,642,673	16.1 kb	Distal (>10kb) Multiome	919
chr9:129,802,988–129,803,555	177.0 kb	Distal (>10kb) Multiome	727
chr9:129,835,192–129,835,687	209.2 kb	Distal (>10kb) Multiome	701

Genome Browser

Genomic view of the NTMT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.