This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NT5M. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NT5M upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NT5M, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:17,041,875–17,042,877 | 261.0 kb | Distal (>10kb) Multiome | 589 | |
| chr17:17,236,752–17,237,798 | 66.0 kb | Distal (>10kb) Multiome | 841 | |
| chr17:17,280,620–17,281,467 | 22.3 kb | Distal (>10kb) Multiome | 835 | |
| chr17:17,300,712–17,301,575 | 2.1 kb | Proximal (<10kb) Multiome | 301 | |
| chr17:17,303,177–17,303,990 | 137 bp | At TSS Multiome | 535 | |
| chr17:17,476,268–17,477,427 | 173.7 kb | Distal (>10kb) Multiome | 720 | |
| chr17:17,494,918–17,497,329 | 193.1 kb | Distal (>10kb) Multiome | 704 | |
| chr17:17,591,221–17,592,219 | 288.4 kb | Distal (>10kb) Multiome | 945 |
Genomic view of the NT5M locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.