Predicted to enable 5'-nucleotidase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NT5C3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NT5C3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NT5C3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:41,548,740–41,549,518 | 287.1 kb | Distal (>10kb) Multiome | 698 | |
| chr17:41,579,549–41,580,064 | 256.5 kb | Distal (>10kb) Multiome | 335 | |
| chr17:41,647,765–41,648,495 | 188.2 kb | Distal (>10kb) Multiome | 519 | |
| chr17:41,662,549–41,663,015 | 173.4 kb | Distal (>10kb) Multiome | 643 | |
| chr17:41,665,564–41,667,291 | 169.0 kb | Distal (>10kb) Multiome | 883 | |
| chr17:41,688,103–41,690,064 | 147.4 kb | Distal (>10kb) Multiome | 1236 | |
| chr17:41,733,761–41,735,187 | 101.5 kb | Distal (>10kb) Multiome | 577 | |
| chr17:41,738,054–41,738,690 | 98.0 kb | Distal (>10kb) Multiome | 596 | |
| chr17:41,784,980–41,787,229 | 49.4 kb | Distal (>10kb) Multiome | 958 | |
| chr17:41,793,527–41,794,326 | 42.4 kb | Distal (>10kb) Multiome | 597 | |
| chr17:41,800,647–41,802,040 | 34.3 kb | Distal (>10kb) Multiome | 766 | |
| chr17:41,811,252–41,813,275 | 23.3 kb | Distal (>10kb) Multiome | 997 | |
| chr17:41,835,756–41,836,400 | 43 bp | At TSS Multiome | 568 | |
| chr17:41,864,608–41,865,695 | 29.2 kb | Distal (>10kb) Multiome | 913 | |
| chr17:41,913,670–41,914,569 | 77.8 kb | Distal (>10kb) Multiome | 190 | |
| chr17:41,918,026–41,919,794 | 83.0 kb | Distal (>10kb) Multiome | 956 | |
| chr17:41,930,220–41,930,908 | 94.3 kb | Distal (>10kb) Multiome | 915 | |
| chr17:41,965,771–41,967,327 | 130.5 kb | Distal (>10kb) Multiome | 920 | |
| chr17:42,016,953–42,018,102 | 181.2 kb | Distal (>10kb) Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 183.8 kb | Distal (>10kb) Multiome | 791 | |
| chr17:42,050,326–42,051,046 | 214.4 kb | Distal (>10kb) Multiome | 514 | |
| chr17:42,107,497–42,108,335 | 271.6 kb | Distal (>10kb) Multiome | 357 | |
| chr17:42,120,858–42,121,715 | 285.0 kb | Distal (>10kb) Multiome | 559 | |
| chr17:42,122,176–42,123,003 | 286.5 kb | Distal (>10kb) Multiome | 169 |
Genomic view of the NT5C3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.