This locus represents a transcribed pseudogene of a nearby locus on chromosome 7, which encodes a putative methyltransferase. There is also a third closely related pseudogene locus in this region. There is extensive alternative splicing at this locus. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for NSUN5P2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NSUN5P2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NSUN5P2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:72,827,875–72,828,778 | 126.5 kb | Distal (>10kb) Multiome | 475 | |
| chr7:72,829,057–72,830,233 | 125.3 kb | Distal (>10kb) Multiome | 511 | |
| chr7:72,879,029–72,879,545 | 75.5 kb | Distal (>10kb) Multiome | 361 | |
| chr7:72,924,558–72,925,695 | 29.7 kb | Distal (>10kb) Multiome | 687 | |
| chr7:73,005,475–73,006,421 | 51.1 kb | Distal (>10kb) Multiome | 385 | |
| chr7:73,154,498–73,155,039 | 200.0 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the NSUN5P2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.