Enables mRNA (cytidine-5-)-methyltransferase activity and rRNA (cytosine-C5-)-methyltransferase activity. Involved in mitochondrial RNA catabolic process; mitochondrial RNA modification; and rRNA methylation. Located in mitochondrial matrix. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NSUN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NSUN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NSUN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:46,131,887–46,133,691 | 207.8 kb | Distal (>10kb) Multiome | 1126 | |
| chr1:46,198,117–46,198,832 | 142.3 kb | Distal (>10kb) Multiome | 646 | |
| chr1:46,203,021–46,203,710 | 137.4 kb | Distal (>10kb) Multiome | 394 | |
| chr1:46,246,904–46,248,623 | 93.3 kb | Distal (>10kb) Multiome | 923 | |
| chr1:46,254,338–46,255,513 | 86.1 kb | Distal (>10kb) Multiome | 39 | |
| chr1:46,301,645–46,303,965 | 37.3 kb | Distal (>10kb) Multiome | 1035 | |
| chr1:46,333,550–46,333,959 | 6.8 kb | Proximal (<10kb) | 215 | |
| chr1:46,340,061–46,341,413 | 60 bp | At TSS Multiome | 967 | |
| chr1:46,348,137–46,348,381 | 7.3 kb | Proximal (<10kb) | 406 | |
| chr1:46,394,021–46,394,849 | 53.6 kb | Distal (>10kb) Multiome | 795 | |
| chr1:46,401,942–46,402,392 | 61.4 kb | Distal (>10kb) Multiome | 511 | |
| chr1:46,406,082–46,407,120 | 65.8 kb | Distal (>10kb) Multiome | 299 | |
| chr1:46,442,171–46,443,351 | 101.9 kb | Distal (>10kb) Multiome | 649 | |
| chr1:46,448,113–46,448,679 | 107.7 kb | Distal (>10kb) Multiome | 143 | |
| chr1:46,466,221–46,467,348 | 125.9 kb | Distal (>10kb) Multiome | 398 | |
| chr1:46,489,045–46,490,312 | 148.9 kb | Distal (>10kb) Multiome | 381 | |
| chr1:46,516,974–46,517,563 | 176.4 kb | Distal (>10kb) Multiome | 328 | |
| chr1:46,525,135–46,525,776 | 184.6 kb | Distal (>10kb) Multiome | 169 | |
| chr1:46,526,636–46,527,311 | 186.2 kb | Distal (>10kb) Multiome | 225 | |
| chr1:46,532,918–46,533,689 | 192.4 kb | Distal (>10kb) Multiome | 254 | |
| chr1:46,603,644–46,604,906 | 263.5 kb | Distal (>10kb) Multiome | 784 | |
| chr1:46,616,228–46,617,226 | 275.9 kb | Distal (>10kb) Multiome | 517 |
Genomic view of the NSUN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.