This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for NRTN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRTN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRTN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:5,536,326–5,536,869 | 268.4 kb | Distal (>10kb) Multiome | 306 | |
| chr19:5,567,504–5,568,201 | 237.2 kb | Distal (>10kb) Multiome | 209 | |
| chr19:5,585,656–5,586,338 | 219.0 kb | Distal (>10kb) Multiome | 267 | |
| chr19:5,621,964–5,623,739 | 182.1 kb | Distal (>10kb) Multiome | 857 | |
| chr19:5,679,757–5,681,464 | 124.2 kb | Distal (>10kb) Multiome | 884 | |
| chr19:5,686,329–5,687,994 | 118.1 kb | Distal (>10kb) Multiome | 693 | |
| chr19:5,689,735–5,690,874 | 114.8 kb | Distal (>10kb) Multiome | 960 | |
| chr19:5,719,717–5,721,174 | 84.7 kb | Distal (>10kb) Multiome | 985 | |
| chr19:5,790,527–5,791,509 | 14.2 kb | Distal (>10kb) Multiome | 965 | |
| chr19:5,803,750–5,806,128 | 965 bp | At TSS Multiome | 858 | |
| chr19:5,826,528–5,829,726 | 23.0 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:5,903,474–5,905,358 | 99.5 kb | Distal (>10kb) Multiome | 1027 | |
| chr19:5,977,406–5,978,787 | 173.1 kb | Distal (>10kb) Multiome | 1028 |
Genomic view of the NRTN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.