NR1H4
nuclear receptor subfamily 1 group H member 4 | FXR, HRR-1, HRR1, RIP14

This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]

Biological processes 97 terms
DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulator complex (GO:0090575)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)bile acid and bile salt transport (GO:0015721)bile acid binding (GO:0032052)bile acid binding (GO:0032052)bile acid binding (GO:0032052)bile acid nuclear receptor activity (GO:0038186)bile acid nuclear receptor activity (GO:0038186)bile acid nuclear receptor activity (GO:0038186)cell differentiation (GO:0030154)cell-cell junction assembly (GO:0007043)cellular response to bile acid (GO:1903413)cellular response to bile acid (GO:1903413)cellular response to bile acid (GO:1903413)cellular response to fatty acid (GO:0071398)cellular response to lipopolysaccharide (GO:0071222)chenodeoxycholic acid binding (GO:1902122)cholesterol homeostasis (GO:0042632)cholesterol homeostasis (GO:0042632)chromatin (GO:0000785)chromatin (GO:0000785)defense response to bacterium (GO:0042742)euchromatin (GO:0000791)fatty acid homeostasis (GO:0055089)glucose homeostasis (GO:0042593)intracellular glucose homeostasis (GO:0001678)intracellular glutamate homeostasis (GO:0090461)intracellular receptor signaling pathway (GO:0030522)intracellular triglyceride homeostasis (GO:0035356)negative regulation of apoptotic process (GO:0043066)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of inflammatory response (GO:0050728)negative regulation of inflammatory response (GO:0050728)negative regulation of interleukin-1 production (GO:0032692)negative regulation of interleukin-2 production (GO:0032703)negative regulation of interleukin-6 production (GO:0032715)negative regulation of monocyte chemotactic protein-1 production (GO:0071638)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of tumor necrosis factor production (GO:0032720)negative regulation of tumor necrosis factor production (GO:0032720)negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)negative regulation of type II interferon production (GO:0032689)negative regulation of type II interferon production (GO:0032689)negative regulation of very-low-density lipoprotein particle remodeling (GO:0010903)nuclear receptor activity (GO:0004879)nuclear receptor activity (GO:0004879)nuclear receptor activity (GO:0004879)nuclear receptor activity (GO:0004879)nuclear receptor binding (GO:0016922)nuclear receptor-mediated bile acid signaling pathway (GO:0038185)nuclear receptor-mediated bile acid signaling pathway (GO:0038185)nuclear receptor-mediated bile acid signaling pathway (GO:0038185)nuclear retinoid X receptor binding (GO:0046965)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of adipose tissue development (GO:1904179)positive regulation of ammonia assimilation cycle (GO:2001250)positive regulation of insulin receptor signaling pathway (GO:0046628)positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0035774)positive regulation of interleukin-17 production (GO:0032740)positive regulation of phosphatidic acid biosynthetic process (GO:1905695)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of bile acid biosynthetic process (GO:0070857)regulation of cholesterol metabolic process (GO:0090181)regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)regulation of low-density lipoprotein particle clearance (GO:0010988)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)signaling receptor complex (GO:0043235)toll-like receptor 9 signaling pathway (GO:0034162)transcription cis-regulatory region binding (GO:0000976)transcription coregulator binding (GO:0001221)triglyceride homeostasis (GO:0070328)urea cycle (GO:0000050)zinc ion binding (GO:0008270)
Expression (TPM)
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