Transcription factors with Perturb-seq knockdown data for NQO1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NQO1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NQO1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:69,385,555–69,386,170 | 340.8 kb | Distal (>10kb) Multiome HiCAR | 857 | |
| chr16:69,529,449–69,529,941 | 197.0 kb | Distal (>10kb) Multiome | 450 | |
| chr16:69,565,464–69,566,984 | 160.9 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:69,726,315–69,727,097 | 173 bp | At TSS Multiome | 879 | |
| chr16:69,754,401–69,755,306 | 28.2 kb | Distal (>10kb) Multiome | 922 | |
| chr16:69,762,035–69,762,848 | 35.6 kb | Distal (>10kb) Multiome | 847 |
Genomic view of the NQO1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.