This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for NPB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,636,404–81,637,301 | 265.2 kb | Distal (>10kb) Multiome | 946 | |
| chr17:81,666,251–81,667,166 | 235.6 kb | Distal (>10kb) Multiome | 901 | |
| chr17:81,683,344–81,684,556 | 218.3 kb | Distal (>10kb) Multiome | 926 | |
| chr17:81,702,879–81,703,868 | 198.9 kb | Distal (>10kb) Multiome | 981 | |
| chr17:81,711,721–81,712,812 | 190.0 kb | Distal (>10kb) Multiome | 1056 | |
| chr17:81,832,473–81,833,976 | 69.0 kb | Distal (>10kb) Multiome | 1015 | |
| chr17:81,859,762–81,861,595 | 41.4 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:81,868,421–81,868,978 | 33.7 kb | Distal (>10kb) Multiome | 577 | |
| chr17:81,869,000–81,872,289 | 31.0 kb | Distal (>10kb) Multiome | 1136 | |
| chr17:81,891,143–81,892,257 | 10.5 kb | Distal (>10kb) Multiome | 969 | |
| chr17:81,902,070–81,902,747 | at TSS | At TSS | 453 | |
| chr17:81,910,443–81,911,980 | 9.3 kb | Proximal (<10kb) Multiome | 806 | |
| chr17:81,917,586–81,918,522 | 15.9 kb | Distal (>10kb) Multiome | 619 | |
| chr17:81,923,285–81,923,863 | 21.3 kb | Distal (>10kb) Multiome | 399 | |
| chr17:81,926,141–81,929,133 | 25.7 kb | Distal (>10kb) Multiome | 1034 | |
| chr17:81,936,855–81,937,682 | 35.1 kb | Distal (>10kb) Multiome | 854 | |
| chr17:81,959,299–81,962,169 | 57.5 kb | Distal (>10kb) Multiome | 805 | |
| chr17:81,966,804–81,968,359 | 65.8 kb | Distal (>10kb) Multiome | 908 | |
| chr17:81,976,595–81,978,312 | 75.4 kb | Distal (>10kb) Multiome | 1001 | |
| chr17:82,019,856–82,020,391 | 117.9 kb | Distal (>10kb) Multiome | 436 | |
| chr17:82,022,355–82,024,111 | 120.8 kb | Distal (>10kb) Multiome | 898 | |
| chr17:82,029,976–82,032,662 | 129.7 kb | Distal (>10kb) Multiome | 695 | |
| chr17:82,036,902–82,037,961 | 135.4 kb | Distal (>10kb) Multiome | 892 | |
| chr17:82,051,387–82,052,184 | 149.5 kb | Distal (>10kb) Multiome | 479 | |
| chr17:82,065,558–82,066,150 | 163.6 kb | Distal (>10kb) Multiome | 967 | |
| chr17:82,096,478–82,100,203 | 196.3 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:82,103,334–82,104,356 | 201.3 kb | Distal (>10kb) Multiome | 672 |
Genomic view of the NPB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.