This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for NOXA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOXA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOXA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:137,129,244–137,130,499 | 293.6 kb | Distal (>10kb) Multiome | 823 | |
| chr9:137,167,984–137,170,155 | 253.9 kb | Distal (>10kb) Multiome | 560 | |
| chr9:137,188,099–137,189,538 | 234.7 kb | Distal (>10kb) Multiome | 954 | |
| chr9:137,200,175–137,201,689 | 222.5 kb | Distal (>10kb) Multiome | 856 | |
| chr9:137,205,371–137,205,975 | 217.7 kb | Distal (>10kb) Multiome | 758 | |
| chr9:137,221,373–137,224,294 | 201.5 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,227,249–137,228,051 | 195.7 kb | Distal (>10kb) Multiome | 533 | |
| chr9:137,236,161–137,237,143 | 186.7 kb | Distal (>10kb) Multiome | 748 | |
| chr9:137,239,991–137,242,933 | 182.4 kb | Distal (>10kb) Multiome | 1117 | |
| chr9:137,243,659–137,245,307 | 179.1 kb | Distal (>10kb) Multiome | 471 | |
| chr9:137,253,801–137,256,036 | 168.1 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,280,593–137,281,861 | 142.2 kb | Distal (>10kb) Multiome | 223 | |
| chr9:137,294,859–137,296,916 | 127.9 kb | Distal (>10kb) Multiome | 501 | |
| chr9:137,300,591–137,303,141 | 120.9 kb | Distal (>10kb) Multiome HiCAR | 790 | |
| chr9:137,316,104–137,316,916 | 107.1 kb | Distal (>10kb) Multiome | 395 | |
| chr9:137,406,843–137,407,556 | 16.2 kb | Distal (>10kb) Multiome | 427 | |
| chr9:137,422,664–137,424,024 | 111 bp | At TSS Multiome | 896 | |
| chr9:137,441,270–137,441,970 | 18.2 kb | Distal (>10kb) Multiome | 568 | |
| chr9:137,453,153–137,455,543 | 30.7 kb | Distal (>10kb) Multiome | 727 | |
| chr9:137,458,468–137,459,887 | 36.0 kb | Distal (>10kb) Multiome | 613 | |
| chr9:137,461,555–137,462,160 | 38.5 kb | Distal (>10kb) Multiome | 284 | |
| chr9:137,551,136–137,552,512 | 128.4 kb | Distal (>10kb) Multiome | 756 | |
| chr9:137,578,523–137,579,553 | 155.5 kb | Distal (>10kb) Multiome | 910 | |
| chr9:137,589,526–137,591,323 | 167.2 kb | Distal (>10kb) Multiome | 623 | |
| chr9:137,604,440–137,607,003 | 182.0 kb | Distal (>10kb) Multiome | 675 | |
| chr9:137,618,064–137,619,880 | 195.6 kb | Distal (>10kb) Multiome | 867 |
Genomic view of the NOXA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.