Enables Notch binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Predicted to be located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for NOTCH2NLA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOTCH2NLA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOTCH2NLA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:145,932,283–145,933,321 | 296.3 kb | Distal (>10kb) Multiome | 308 | |
| chr1:145,957,545–145,958,280 | 271.0 kb | Distal (>10kb) Multiome | 631 | |
| chr1:145,960,287–145,961,311 | 268.3 kb | Distal (>10kb) Multiome | 498 | |
| chr1:145,964,302–145,964,971 | 264.4 kb | Distal (>10kb) Multiome | 662 | |
| chr1:145,978,977–145,980,010 | 249.5 kb | Distal (>10kb) Multiome | 689 | |
| chr1:145,996,493–145,997,058 | 232.3 kb | Distal (>10kb) Multiome | 911 | |
| chr1:146,035,364–146,036,312 | 193.4 kb | Distal (>10kb) Multiome | 845 | |
| chr1:146,036,931–146,039,723 | 191.9 kb | Distal (>10kb) Multiome | 1048 | |
| chr1:146,051,092–146,052,696 | 176.8 kb | Distal (>10kb) Multiome | 1182 | |
| chr1:146,376,366–146,377,595 | 148.0 kb | Distal (>10kb) Multiome | 815 | |
| chr1:146,387,171–146,387,715 | 158.5 kb | Distal (>10kb) Multiome | 638 | |
| chr1:146,409,828–146,410,660 | 181.0 kb | Distal (>10kb) Multiome | 435 |
Genomic view of the NOTCH2NLA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.