Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for NOM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:155,466,156–155,467,479 | 1482.8 kb | Distal (>10kb) Multiome HiCAR | 270 | |
| chr7:155,467,594–155,468,737 | 1481.5 kb | Distal (>10kb) Multiome HiCAR | 231 | |
| chr7:156,892,088–156,893,883 | 56.4 kb | Distal (>10kb) Multiome | 1026 | |
| chr7:156,942,807–156,943,028 | 6.7 kb | Proximal (<10kb) | 124 | |
| chr7:156,948,934–156,950,397 | 38 bp | At TSS Multiome | 895 | |
| chr7:156,951,698–156,951,880 | 2.0 kb | Proximal (<10kb) | 43 | |
| chr7:157,003,648–157,004,372 | 54.4 kb | Distal (>10kb) Multiome | 255 | |
| chr7:157,009,113–157,012,019 | 61.1 kb | Distal (>10kb) Multiome | 793 | |
| chr7:157,013,630–157,014,425 | 64.4 kb | Distal (>10kb) Multiome | 180 | |
| chr7:157,020,746–157,021,949 | 71.5 kb | Distal (>10kb) Multiome | 146 | |
| chr7:157,138,376–157,139,695 | 189.1 kb | Distal (>10kb) Multiome | 863 |
Genomic view of the NOM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.