NLRC3
NLR family CARD domain containing 3 | CLR16.2, FLJ00348, NOD3

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Biological processes 34 terms
T cell activation (GO:0042110)canonical NF-kappaB signal transduction (GO:0007249)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)negative regulation of NLRP3 inflammasome complex assembly (GO:1900226)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of cytokine production involved in inflammatory response (GO:1900016)negative regulation of epithelial cell proliferation (GO:0050680)negative regulation of fibroblast proliferation (GO:0048147)negative regulation of immune system process (GO:0002683)negative regulation of inflammatory response (GO:0050728)negative regulation of inflammatory response (GO:0050728)negative regulation of inflammatory response (GO:0050728)negative regulation of innate immune response (GO:0045824)negative regulation of innate immune response (GO:0045824)negative regulation of interferon-alpha production (GO:0032687)negative regulation of interferon-beta production (GO:0032688)negative regulation of interleukin-6 production (GO:0032715)negative regulation of interleukin-6 production (GO:0032715)negative regulation of interleukin-6 production (GO:0032715)negative regulation of non-canonical NF-kappaB signal transduction (GO:1901223)negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)negative regulation of tumor necrosis factor production (GO:0032720)negative regulation of tumor necrosis factor production (GO:0032720)negative regulation of tumor necrosis factor production (GO:0032720)perinuclear region of cytoplasm (GO:0048471)phosphatidylinositol 3-kinase regulatory subunit binding (GO:0036312)protein binding (GO:0005515)regulation of innate immune response (GO:0045088)
Expression (TPM)
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