NKIRAS2

NFKB inhibitor interacting Ras like 2 | DKFZP434N1526, KBRAS2, kappaB-Ras2

Predicted to enable GTPase activating protein binding activity. Predicted to be involved in Ral protein signal transduction. Predicted to act upstream of or within several processes, including lung alveolus development; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 10 terms

GTP binding (GO:0005525)GTPase activating protein binding (GO:0032794)GTPase activating protein binding (GO:0032794)GTPase activity (GO:0003924)GTPase activity (GO:0003924)Ral protein signal transduction (GO:0032484)cytoplasm (GO:0005737)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)protein binding (GO:0005515)

Expression (TPM)

TFs regulating NKIRAS2 0 TFs

Transcription factors with Perturb-seq knockdown data for NKIRAS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NKIRAS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NKIRAS2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NKIRAS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:41,733,761–41,735,187	285.4 kb	Distal (>10kb) Multiome	577
chr17:41,738,054–41,738,690	281.9 kb	Distal (>10kb) Multiome	596
chr17:41,784,980–41,787,229	233.3 kb	Distal (>10kb) Multiome	958
chr17:41,793,527–41,794,326	226.2 kb	Distal (>10kb) Multiome	597
chr17:41,800,647–41,802,040	218.2 kb	Distal (>10kb) Multiome	766
chr17:41,811,252–41,813,275	207.1 kb	Distal (>10kb) Multiome	997
chr17:41,835,756–41,836,400	183.9 kb	Distal (>10kb) Multiome	568
chr17:41,864,608–41,865,695	154.7 kb	Distal (>10kb) Multiome	913
chr17:41,913,670–41,914,569	106.0 kb	Distal (>10kb) Multiome	190
chr17:41,918,026–41,919,794	100.9 kb	Distal (>10kb) Multiome	956
chr17:41,930,220–41,930,908	89.6 kb	Distal (>10kb) Multiome	915
chr17:41,965,771–41,967,327	53.3 kb	Distal (>10kb) Multiome	920
chr17:42,016,953–42,018,102	2.6 kb	Proximal (<10kb) Multiome	991
chr17:42,019,726–42,020,334	51 bp	At TSS Multiome	791
chr17:42,024,991–42,025,187	4.9 kb	Proximal (<10kb)	476
chr17:42,028,623–42,028,831	8.5 kb	Proximal (<10kb)	240
chr17:42,050,326–42,051,046	30.5 kb	Distal (>10kb) Multiome	514
chr17:42,107,497–42,108,335	87.8 kb	Distal (>10kb) Multiome HiCAR	357
chr17:42,120,858–42,121,715	101.2 kb	Distal (>10kb) Multiome	559
chr17:42,122,176–42,123,003	102.6 kb	Distal (>10kb) Multiome	169
chr17:42,154,717–42,156,309	135.0 kb	Distal (>10kb) Multiome	770
chr17:42,180,242–42,180,762	160.3 kb	Distal (>10kb) Multiome	576
chr17:42,183,755–42,184,761	164.1 kb	Distal (>10kb) Multiome	810
chr17:42,275,506–42,277,052	256.3 kb	Distal (>10kb) Multiome	892
chr17:42,288,257–42,288,808	268.4 kb	Distal (>10kb) Multiome	449
chr17:42,312,237–42,312,887	292.4 kb	Distal (>10kb) Multiome	774

Genome Browser

Genomic view of the NKIRAS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.