Enables transcription coactivator activity. Involved in several processes, including gonadotropin secretion; negative regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Located in several cellular components, including adherens junction; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NIBAN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NIBAN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NIBAN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,396,281–127,398,388 | 172.1 kb | Distal (>10kb) Multiome | 843 | |
| chr9:127,423,809–127,424,734 | 144.8 kb | Distal (>10kb) Multiome | 791 | |
| chr9:127,450,607–127,452,473 | 117.7 kb | Distal (>10kb) Multiome | 1009 | |
| chr9:127,567,936–127,569,972 | 123 bp | At TSS Multiome | 660 | |
| chr9:127,578,969–127,579,236 | 9.9 kb | Proximal (<10kb) | 570 | |
| chr9:127,608,129–127,608,913 | 39.5 kb | Distal (>10kb) Multiome | 700 | |
| chr9:127,611,734–127,612,761 | 43.1 kb | Distal (>10kb) Multiome | 566 | |
| chr9:127,699,155–127,699,632 | 130.4 kb | Distal (>10kb) Multiome | 440 | |
| chr9:127,715,013–127,716,345 | 146.7 kb | Distal (>10kb) Multiome | 735 | |
| chr9:127,734,444–127,735,606 | 166.2 kb | Distal (>10kb) Multiome | 836 | |
| chr9:127,741,739–127,743,092 | 173.8 kb | Distal (>10kb) Multiome | 367 | |
| chr9:127,754,123–127,755,506 | 186.3 kb | Distal (>10kb) Multiome | 279 | |
| chr9:127,770,807–127,771,925 | 202.4 kb | Distal (>10kb) Multiome | 550 | |
| chr9:127,784,682–127,787,009 | 217.5 kb | Distal (>10kb) Multiome | 858 | |
| chr9:127,802,385–127,803,632 | 233.9 kb | Distal (>10kb) Multiome | 867 | |
| chr9:127,809,338–127,810,272 | 240.8 kb | Distal (>10kb) Multiome | 276 | |
| chr9:127,825,222–127,826,046 | 256.6 kb | Distal (>10kb) Multiome | 451 | |
| chr9:127,828,234–127,829,024 | 259.5 kb | Distal (>10kb) Multiome | 521 |
Genomic view of the NIBAN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.