The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for NFKBIE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFKBIE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFKBIE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:44,254,609–44,255,697 | 9.9 kb | Proximal (<10kb) | 430 | |
| chr6:44,256,209–44,258,064 | 7.5 kb | Proximal (<10kb) | 1042 | |
| chr6:44,264,892–44,265,788 | at TSS | At TSS | 760 | |
| chr6:44,268,099–44,268,513 | 2.5 kb | Proximal (<10kb) | 314 | |
| chr6:44,270,373–44,271,349 | 4.8 kb | Proximal (<10kb) | 166 |
Genomic view of the NFKBIE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.