Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent endocytosis. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NEURL1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEURL1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEURL1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:172,453,197–172,453,607 | 188.1 kb | Distal (>10kb) Multiome | 249 | |
| chr5:172,453,730–172,456,312 | 186.7 kb | Distal (>10kb) Multiome | 677 | |
| chr5:172,478,999–172,479,594 | 162.0 kb | Distal (>10kb) Multiome HiCAR | 365 | |
| chr5:172,640,809–172,642,014 | 18 bp | At TSS Multiome | 468 | |
| chr5:172,646,972–172,647,140 | 5.7 kb | Proximal (<10kb) | 50 | |
| chr5:172,683,287–172,684,318 | 42.8 kb | Distal (>10kb) Multiome | 215 | |
| chr5:172,697,353–172,697,964 | 56.4 kb | Distal (>10kb) Multiome | 445 | |
| chr5:172,700,111–172,700,934 | 59.2 kb | Distal (>10kb) Multiome | 131 | |
| chr5:172,765,066–172,765,738 | 124.1 kb | Distal (>10kb) Multiome | 748 | |
| chr5:172,769,970–172,772,642 | 130.0 kb | Distal (>10kb) Multiome | 1190 | |
| chr5:172,833,492–172,835,141 | 193.0 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the NEURL1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.