Predicted to enable translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for NEURL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEURL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEURL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:103,204,930–103,206,025 | 288.6 kb | Distal (>10kb) Multiome | 207 | |
| chr10:103,276,757–103,278,251 | 216.5 kb | Distal (>10kb) Multiome | 385 | |
| chr10:103,350,520–103,351,294 | 142.7 kb | Distal (>10kb) Multiome | 679 | |
| chr10:103,367,765–103,368,860 | 125.1 kb | Distal (>10kb) Multiome | 925 | |
| chr10:103,395,952–103,396,926 | 97.1 kb | Distal (>10kb) Multiome | 821 | |
| chr10:103,485,793–103,485,970 | 7.7 kb | Proximal (<10kb) | 177 | |
| chr10:103,493,310–103,494,526 | 43 bp | At TSS Multiome | 299 | |
| chr10:103,542,810–103,543,379 | 49.4 kb | Distal (>10kb) Multiome HiCAR | 294 | |
| chr10:103,661,427–103,661,981 | 168.0 kb | Distal (>10kb) Multiome | 301 | |
| chr10:103,692,163–103,693,782 | 198.7 kb | Distal (>10kb) Multiome | 288 | |
| chr10:103,771,858–103,772,878 | 278.8 kb | Distal (>10kb) Multiome | 532 |
Genomic view of the NEURL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.