Transcription factors with Perturb-seq knockdown data for NETO1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NETO1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NETO1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:72,692,057–72,692,906 | 176.0 kb | Distal (>10kb) Multiome | 173 | |
| chr18:72,866,437–72,870,294 | 352 bp | At TSS Multiome | 424 | |
| chr18:72,878,165–72,878,461 | 9.8 kb | Proximal (<10kb) | 46 | |
| chr18:74,147,321–74,148,959 | 1280.0 kb | Distal (>10kb) Multiome HiCAR | 990 |
Genomic view of the NETO1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.