Predicted to be involved in negative regulation of neuron differentiation and positive regulation of Notch signaling pathway. Predicted to be located in nucleolus. Predicted to be active in nucleus. Implicated in anauxetic dysplasia 3. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NEPRO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEPRO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEPRO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:112,560,905–112,563,207 | 457.6 kb | Distal (>10kb) Multiome HiCAR | 967 | |
| chr3:112,785,378–112,786,966 | 233.4 kb | Distal (>10kb) Multiome | 290 | |
| chr3:112,990,506–112,991,646 | 28.6 kb | Distal (>10kb) Multiome | 925 | |
| chr3:113,018,819–113,020,010 | 36 bp | At TSS Multiome | 965 | |
| chr3:113,210,367–113,212,837 | 192.3 kb | Distal (>10kb) Multiome | 482 | |
| chr3:113,240,837–113,244,224 | 222.1 kb | Distal (>10kb) Multiome | 545 |
Genomic view of the NEPRO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.