Predicted to enable protein kinase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within positive regulation of striated muscle cell differentiation. Located in sperm flagellum. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for NEK5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEK5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEK5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:52,011,124–52,012,698 | 116.9 kb | Distal (>10kb) Multiome | 960 | |
| chr13:52,127,639–52,128,069 | 1.0 kb | Proximal (<10kb) | 387 | |
| chr13:52,128,284–52,129,389 | 20 bp | At TSS Multiome | 598 | |
| chr13:52,159,155–52,160,117 | 30.5 kb | Distal (>10kb) Multiome | 831 | |
| chr13:52,194,155–52,194,839 | 65.4 kb | Distal (>10kb) Multiome | 888 | |
| chr13:52,195,279–52,195,948 | 66.6 kb | Distal (>10kb) Multiome | 267 |
Genomic view of the NEK5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.