Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NEK10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEK10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEK10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:27,368,750–27,369,718 | 11 bp | At TSS Multiome | 567 | |
| chr3:27,483,148–27,485,398 | 115.1 kb | Distal (>10kb) Multiome | 917 | |
| chr3:27,532,531–27,534,712 | 164.5 kb | Distal (>10kb) Multiome | 739 | |
| chr3:27,632,489–27,633,437 | 263.5 kb | Distal (>10kb) Multiome | 378 | |
| chr3:27,680,718–27,681,875 | 311.7 kb | Distal (>10kb) Multiome HiCAR | 532 |
Genomic view of the NEK10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.