This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for NEIL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEIL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEIL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:74,889,894–74,890,629 | 457.5 kb | Distal (>10kb) Multiome HiCAR | 816 | |
| chr15:75,140,133–75,140,707 | 207.2 kb | Distal (>10kb) Multiome | 536 | |
| chr15:75,178,233–75,178,833 | 169.1 kb | Distal (>10kb) Multiome | 386 | |
| chr15:75,200,527–75,203,502 | 145.6 kb | Distal (>10kb) Multiome | 928 | |
| chr15:75,335,855–75,336,339 | 11.6 kb | Distal (>10kb) Multiome | 665 | |
| chr15:75,346,877–75,348,733 | 177 bp | At TSS Multiome | 738 | |
| chr15:75,367,625–75,369,002 | 20.5 kb | Distal (>10kb) Multiome | 1121 | |
| chr15:75,450,273–75,456,388 | 108.3 kb | Distal (>10kb) Multiome | 1174 | |
| chr15:75,579,138–75,580,015 | 231.9 kb | Distal (>10kb) Multiome | 683 | |
| chr15:75,624,816–75,626,356 | 278.1 kb | Distal (>10kb) Multiome | 987 | |
| chr15:75,639,562–75,640,798 | 292.7 kb | Distal (>10kb) Multiome HiCAR | 999 | |
| chr15:75,647,017–75,648,674 | 300.2 kb | Distal (>10kb) Multiome | 795 |
Genomic view of the NEIL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.