Transcription factors with Perturb-seq knockdown data for NECTIN3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NECTIN3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NECTIN3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:111,063,188–111,064,109 | 7.4 kb | Proximal (<10kb) | 73 | |
| chr3:111,070,119–111,072,931 | 78 bp | At TSS Multiome | 745 | |
| chr3:111,076,700–111,076,996 | 5.1 kb | Proximal (<10kb) | 33 | |
| chr3:111,080,467–111,080,609 | 8.9 kb | Proximal (<10kb) | 66 |
Genomic view of the NECTIN3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.